Recombinant PE Anti-SOX10 antibody [SP267] (ab270152) (2024)

Overview

• Product name

  PE Anti-SOX10 antibody [SP267]
  See all SOX10 primary antibodies

• Description

  PE Rabbit monoclonal [SP267] to SOX10

• Host species

  Rabbit

• Conjugation

  PE. Ex: 488nm, Em: 575nm

• Tested applications

  Suitable for: Flow Cyt (Intra)more details

• Species reactivity

  Reacts with: Human
  

  See Also

  Elements of Corporate Social Responsibility: The Ultimate GuideILM Level 3 Certificate in Effective Coaching and Mentoring Course - MalawiNederlandse Orde van Advocaten - Nederlandse Orde van AdvocatenILM Level 3 Certificate in Effective Coaching and Mentoring Course in Lilongwe

• Immunogen

  Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

• Positive control

  • Flow Cyt (intra): A375 cells

• General notes

  This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free production

  For more information see here.

  Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

• Form

  Liquid

• Storage instructions

  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Avoid freeze / thaw cycle. Store In the Dark.

• Storage buffer

  pH: 7.4
  Preservative: 0.02% Sodium azide
  Constituents: 1% BSA, 98% PBS

• Concentration information loading...

• Clonality

  Monoclonal

• Clone number

  SP267

• Isotype

  IgG

• Research areas

  • Neuroscience
  • Cell Type Marker
  • Neural Stem Cell marker

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HMG Box

  • Stem Cells
  • Lineage Markers
  • Ectoderm

  • Developmental Biology
  • Lineage specification
  • Ectoderm

  • Neuroscience
  • Development

Associated products

• Alternative Versions

  • Alexa Fluor® 555 Anti-SOX10 antibody [SP267] (ab307763)
  • APC Anti-SOX10 antibody [SP267] (ab310845)
  • Alexa Fluor® 594 Anti-SOX10 antibody [SP267] (ab311668)
  • Alexa Fluor® 568 Anti-SOX10 antibody [SP267] (ab313897)

• Isotype control

  • PE Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab209478)

Applications

Target

• Function

  Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia.

• Tissue specificity

  Expressed in fetal brain and in adult brain, heart, small intestine and colon.

• Involvement in disease

  Defects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E) [MIM:611584]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.
  Defects in SOX10 are a cause of Waardenburg syndrome type 4C (WS4C) [MIM:613266]; also known as Waardenburg-Shah syndrome. WS4C is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
  Defects in SOX10 are a cause of Yemenite deaf-blind hypopigmentation syndrome (YDBHS) [MIM:601706]. YDBHS consists of cutaneous hypopigmented and hyperpigmented spots and patches, microcornea, coloboma and severe hearing loss. Another case observed in a girl with similar skin symptoms and hearing loss but without microcornea or coloboma is reported as a mild form of this syndrome.
  Defects in SOX10 are the cause of peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease (PCWH) [MIM:609136]; also called neurologic variant of Waardenburg-Shah syndrome. PCWH is a rare, complex and more severe neurocristopathy that includes features of 4 distinct syndromes: peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease.

• Sequence similarities

  Contains 1 HMG box DNA-binding domain.

• Cellular localization

  Cytoplasm. Nucleus.

• Information by UniProt

• Database links

  • Entrez Gene: 6663 Human
  • Omim: 602229 Human
  • SwissProt: P56693 Human
  • Unigene: 376984 Human

• Alternative names

  • DOM antibody
  • DOM antibody
  • Dominant megacolon mouse human hom*olog of antibody

  see all

Images

Protocols

Datasheets and documents

References (0)